Um, guys?

Um, guys? Hey, guys? The proteins in mosquito saliva are the primary hypothesis as to the cause of the rare but real allergy thereto. I don't mean the usual itching. I mean goes all the way to anaphylaxis, you know, unpleasant dying.

I really hope you have a lot of benadryl and steroids around for your study participants, because sure, they haven't developed that level of sensitivity after presumed repeated mosquito bites over their lifetime. However, they also haven't been deliberately given concentrated doses of those salivary proteins, either, in a deliberate attempt to stimulate the immune system in one way and not another. (I am assuming they know there is a small but real prevalence of allergy to mosquito bites and that's an exclusion for study participation.)

It's super important to have vaccines against these mosquito-borne viruses, but are you monitoring for that level of severe allergic reaction? And are you going to pay attention to early and late phase potential allergic reactions? Because I know you aren't keeping them in your clinic for 24-48 hours.

https://medicalxpress.com/news/2017-02-mosquito-saliva-vaccine-nih-illness.html


https://medicalxpress.com/news/2017-02-mosquito-saliva-vaccine-nih-illness.html